All future Anti-Piracy ROMs are not supported but could possibly be fixed on a 1:1 basis. You will need to rename your save files in order to make use of them. Including Wii-connectivity, Cheats, Themes, Short-cuts, etc. However, it has not been updated since April 24, 2008. However, NDSTokyo Trim is widely considered to be the best trimmer at this time. I won't say it is 100% because there could be the occasional glitch or bug. Firmware 1.18 is the latest official firmware for the R4DS.Some homebrew made with the PAlib library do not function properly*, leading to loss of touchscreen use, sound and/or choppy graphics. Some homebrew may require manual DLDI patching to work.
NOTE: Since the release of Wood R4 and the lack of unofficial updates for DSTT firmware, this firmware is not highly recommended.
You can download the latest TTDS EXT, INFO, SAV files here.