She is known for her film roles in John Tucker Must Die (2006), The Hitcher (2007), and The Narrows (2008). At Westridge, she was required to participate in the theatre arts program.
In 2014, she began starring in the NBC police procedural drama series Chicago P. Bush stated: "Part of my school's requirement was to do a play.
In 2003, Bush was cast as Kate Brewster in Terminator 3: Rise of the Machines, though she was replaced by Claire Danes after a week of filming.
Finally, in May 2010, Bush confirmed that she and Nichols have been an item for at least four years.
A couple years later, she began dating James Lafferty. She was first married to former series star Chad Michael Murray before they divorced in December 2006.